Control of cellular metabolism is critical for efficient cell function, although little is known
about the interplay between cell subset–specific metabolites in situ, especially in the tumor …

Macrophages are often prominently present in the tumor microenvironment, where distinct
macrophage populations can differentially affect tumor progression. Although metabolism …

Ovarian cancer is an intra-abdominal tumor in which the presence of ascites facilitates
metastatic dissemination, and associated with poor prognosis. However, the significance of …

Tumor-associated macrophages (TAMs) affect cancer progression and therapy. Ovarian
carcinoma often metastasizes to the peritoneal cavity. Here, we found 2 peritoneal …

In the tumor microenvironment, adipocytes function as an alternate fuel source for cancer
cells. However, whether adipocytes influence macromolecular biosynthesis in cancer cells is …

Simple Summary Tumors often include many immune cells that are theoretically able to
combat tumor growth. Yet, tumors can induce immune functions that support tumor growth …

Tumor-associated macrophages (TAMs) are a major cellular component in the tumor
microenvironment (TME). However, the relationship between the phenotype and metabolic …

Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying
inflammatory macrophage activation. During this process, endogenous metabolites can …

To uncover underlying mechanisms associated with failure of indoleamine 2, 3-dioxygenase
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical study …

Background Tumor-associated macrophages (TAMs) are key components of the tumor
microenvironment (TME) in non-medullary thyroid carcinoma (TC) and neuroblastoma (NB) …