Purpose To evaluate the efficacy of combined vitamin C, hydrocortisone, and thiamine in
patients with severe pneumonia. Materials and methods All consecutive patients with severe …

Background Critically ill patients frequently suffer from vitamin C deficiency. Previous studies
showed that high doses of vitamin C administration had conflicting results on clinical …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Background Sepsis and septic shock are medical emergencies resulting in significant
morbidity and mortality. Intravenous (IV) vitamin C, thiamine, and hydrocortisone have …

A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine
combination therapy (triple therapy) in addition to standard care in patients with severe …

OBJECTIVES: To determine whether IV vitamin C therapy reduces 28-day mortality in
patients with septic shock. DESIGN: Multicenter, double-blinded, randomized controlled trial …

Importance Sepsis is a common syndrome with substantial morbidity and mortality. A
combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential …

Background Sepsis accounts for 30% to 50% of all in-hospital deaths in the United States.
Other than antibiotics and source control, management strategies are largely supportive with …

Rationale: In December 2016, a single-center study describing significant improvements in
mortality among a small group of patients with severe sepsis and septic shock treated with …

Background Sepsis remains a leading cause of death worldwide despite advances in
management strategies. Preclinical and observational studies have found mortality benefit …