Role of integrin signaling activation on the development of human T cell leukemia Virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis: Its …

T Nakamura, K Satoh, H Nakamura… - AIDS Research and …, 2018 - liebertpub.com
The main clinical feature of human T cell leukemia virus-1 (HTLV-1)-associated
myelopathy/tropical spastic paraparesis (HAM/TSP) is slowly progressive spastic …

HAM/TSP pathogenesis: the transmigration activity of HTLV-1-Infected T cells into tissues

T Nakamura - Pathogens, 2023 - mdpi.com
Slowly progressive spastic paraparesis with bladder dysfunction, the main clinical feature of
human T-cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis …

Immunopathogenesis of human T‐cell leukemia virus type‐1‐associated myelopathy/tropical spastic paraparesis: recent perspectives

M Saito, CRM Bangham - Leukemia research and treatment, 2012 - Wiley Online Library
Human T‐cell leukemia virus type‐1 (HTLV‐1) is a replication‐competent human retrovirus
associated with two distinct types of disease only in a minority of infected individuals: the …

Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP)

HT Fuzii, GA da Silva Dias, RJS de Barros, LFM Falcão… - Life sciences, 2014 - Elsevier
Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell
leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis …

CD49d is upregulated in circulating T lymphocytes from HTLV-1-infected patients

LT Janahú, CA Da Costa, ACR Vallinoto… - …, 2021 - karger.com
Abstract Introduction: HTLV-1-associated myelopathy/tropical spastic paraparesis
(HAM/TSP) is a chronic progressive myelopathy associated with an inflammation of the …

Increased expression of α4β1 and α5β1 integrins on HTLV-I-infected lymphocytes

S Dhawan, BS Weeks, F Abbasi, HR Gralnick… - Virology, 1993 - Elsevier
T cells interact with the extracellular matrix via integrin receptors and these interactions
affect both cellular localization and proliferation. The importance of these interactions in …

Blockade of IL-2 receptor suppresses HTLV-I and IFN-γ expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

N Fukushima, Y Nishiura, T Nakamura, S Kohno… - Internal …, 2007 - jstage.jst.go.jp
Objective: Th1 activation based on a high HTLV-I proviral load is one of the characteristic
immunological abnormalities in the peripheral blood lymphocytes of patients with HTLV-I …

HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T cells …

ES Gudo, SD Silva-Barbosa, L Linhares-Lacerda… - Virology Journal, 2015 - Springer
Background The mechanisms through which HTLV-1 leads to and maintains damage in the
central nervous system of patients undergoing HTLV-1 associated myelopathy/tropical …

Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis

K Barmak, EW Harhaj, B Wigdahl - Journal of neurovirology, 2003 - Springer
Human T-cell leukemia virus type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) represents one of the most devastating diseases associated with …

Immunopathogenesis and cellular interactions in human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis

S Aghajanian, M Teymoori-Rad, G Molaverdi… - Frontiers in …, 2020 - frontiersin.org
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a
neuropathological disorder in 1–3% of individuals infected with Human T-lymphotropic virus …