Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

DV Zhernakova, TH Le, A Kurilshikov, B Atanasovska… - Nature …, 2018 - nature.com
Despite a growing body of evidence, the role of the gut microbiome in cardiovascular
diseases is still unclear. Here, we present a systems-genome-wide and metagenome-wide …

Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease

RL Walker, H Vlamakis, JWJ Lee, LA Besse… - Genome medicine, 2021 - Springer
Background The human gut harbors trillions of microbes that play dynamic roles in health.
While the microbiome contributes to many cardiometabolic traits by modulating host …

The gut microbiome in atherosclerotic cardiovascular disease

Z Jie, H Xia, SL Zhong, Q Feng, S Li, S Liang… - Nature …, 2017 - nature.com
The gut microbiota has been linked to cardiovascular diseases. However, the composition
and functional capacity of the gut microbiome in relation to cardiovascular diseases have not …

Gut microbiome associations with host genotype vary across ethnicities and potentially influence cardiometabolic traits

U Boulund, DM Bastos, B Ferwerda, BJ van den Born… - Cell host & …, 2022 - cell.com
Previous studies in mainly European populations have reported that the gut microbiome
composition is associated with the human genome. However, the genotype-microbiome …

The gut microbiome contributes to a substantial proportion of the variation in blood lipids

J Fu, MJ Bonder, MC Cenit, EF Tigchelaar… - Circulation …, 2015 - Am Heart Assoc
Rationale: Evidence suggests that the gut microbiome is involved in the development of
cardiovascular disease, with the host–microbe interaction regulating immune and metabolic …

Gut microbial associations to plasma metabolites linked to cardiovascular phenotypes and risk: a cross-sectional study

A Kurilshikov, ICL van den Munckhof, L Chen… - Circulation …, 2019 - Am Heart Assoc
Rationale: Altered gut microbial composition has been linked to cardiovascular diseases
(CVDs), but its functional links to host metabolism and immunity in relation to CVD …

Host genetic variation impacts microbiome composition across human body sites

R Blekhman, JK Goodrich, K Huang, Q Sun… - Genome biology, 2015 - Springer
Background The composition of bacteria in and on the human body varies widely across
human individuals, and has been associated with multiple health conditions. While microbial …

Gut microbiota composition and blood pressure: the CARDIA study

S Sun, A Lulla, M Sioda, K Winglee, MC Wu… - …, 2019 - Am Heart Assoc
Animal models support a role for the gut microbiota in the development of hypertension.
There has been a lack of epidemiological cohort studies to confirm these findings in human …

Unraveling the environmental and genetic interactions in atherosclerosis: central role of the gut microbiota

E Org, M Mehrabian, AJ Lusis - Atherosclerosis, 2015 - Elsevier
Recent studies have convincingly linked gut microbiota to traits relevant to atherosclerosis,
such as insulin resistance, dyslipidemia and inflammation, and have revealed novel disease …

Causal associations between gut microbiome and cardiovascular disease: a Mendelian randomization study

Y Zhang, X Zhang, D Chen, J Lu, Q Gong… - Frontiers in …, 2022 - frontiersin.org
Background Observational studies have shown gut microbiomes were associated with
cardiovascular diseases (CVDs), but their roles remain controversial, and these associations …