Los factores HIF son heterodímeros compuestos por dos subunidades, α y β. Mientras que
los niveles de HIF-β son constitutivos, la estabilidad y actividad de las subunidades HIF-1α y …

Somatic mutations or loss of von Hippel–Lindau (pVHL) happen in the majority of VHL
disease tumors, which present a constitutively active Hypoxia Inducible Factor (HIF) …

Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor
protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights …

Abstract The von Hippel-Lindau (VHL) tumour suppressor gene encodes a substrate-
specifying component of an E3 ubiquitin ligase that targets hypoxia-inducible factor (HIF) α …

Hypoxia-inducible factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix
transcription factors that play central roles in cellular adaptation to low oxygen environments …

In the present study, the role of the C-terminal α-helical domain (amino acid (aa) 195–208)
of the von Hippel–Lindau (VHL) tumour suppressor was investigated. Deletions of the VHL …

The von Hippel–Lindau (VHL) tumor suppressor protein, the recognition component of an
E3 ubiquitin ligase complex, recruits the α-subunit of the hypoxia-inducible factor (HIFα) for …

Mutations of the von Hippel-Lindau (VHL) gene are frequent in clear cell renal cell
carcinomas (ccRCC). Nonsense and frameshift mutations abrogate the function of the VHL …

Abstract Hypoxia-inducible factor-1α (HIF-1α) induction and associated transcription were
investigated during high cell density, focusing on the negative regulator of HIF-1α …

The physiologic response to changes in cellular oxygen tension is ultimately governed by a
heterodimeric transcription factor called hypoxia-inducible factor (HIF), which, in adaptation …