Background Imaging agents capable of quantifying the brain's tau aggregates will allow a
more precise staging of Alzheimer's disease (AD). The aim of the present study was to …

Purpose Visualization of the spatial distribution of neurofibrillary tangles would help in the
diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate …

Purpose Diagnosis of tauopathies such as Alzheimer's disease (AD) still relies on post-
mortem examination of the human brain. A non-invasive method of determining brain tau …

A PET tracer is desired to help guide the discovery and development of disease-modifying
therapeutics for neurodegenerative diseases characterized by neurofibrillary tangles (NFTs) …

Tau PET imaging has potential for elucidating changes in the deposition of
neuropathological tau aggregates that are occurring during the progression of Alzheimer …

Non-invasive imaging of tau pathology in the living brain would be useful for accurately
diagnosing Alzheimer's disease, tracking disease progression, and evaluating the treatment …

Abstract [F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently
discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve …

Introduction The accumulation of neurofibrillary tangles, composed of aggregated
hyperphosphorylated tau protein, starts spreading early in specific regions in the course of …

While considerable effort has focused on developing positron emission tomography β-
amyloid imaging radiotracers for the early diagnosis of Alzheimer's disease, no radiotracer is …

Imaging of neurofibrillary pathology in the brain helps in diagnosing dementia, tracking
disease progression, and evaluating the therapeutic efficacy of antidementia drugs. The …