Despite its discovery more than three decades ago and well-established role in protein
sorting and trafficking in the early secretory pathway, the intermediate compartment (IC) has …

The intermediate compartment (IC) between the endoplasmic reticulum (ER) and the Golgi
apparatus appears to constitute an autonomous organelle composed of spatially and …

Because the functional borders of the intermediate compartment (IC) are not well defined,
the spatial map of the transport machineries operating between the endoplasmic reticulum …

In higher eukaryotic cells pleiomorphic compartments composed of vacuoles, tubules and
vesicles move from the endoplasmic reticulum (ER) and the plasma membrane to the cell …

Intracellular transport has remained central to cell biology now for more than 40 years.
Despite this, we still lack an overall mechanistic framework that describes transport in …

Biomolecules in the secretory pathway use membrane trafficking for reaching their final
intracellular destination or for secretion outside the cell. This highly dynamic and multipartite …

Recent work supports the idea that cisternae of the Golgi apparatus can be assigned to
three classes, which correspond to discrete stages of cisternal maturation. Each stage has a …

The Golgi apparatus represents a central compartment of membrane traffic. Its apparent
architecture, however, differs considerably among species, from unstacked and scattered …

Integrating the pleomorphic membranes of the intermediate compartment (IC) into the array
of Golgi cisternae is a crucial step in membrane transport, but it is poorly understood. To …

The Golgi apparatus contains multiple classes of cisternae that differ in structure,
composition, and function, but there is no consensus about the number and definition of …