DNA methylation-based classification of central nervous system tumours
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system …
For the approximately 100 known tumour types of the central nervous system …
[HTML][HTML] Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …
DNA methylation profiling as a model for discovery and precision diagnostics in neuro-oncology
Recent years have witnessed a shift to more objective and biologically-driven methods for
central nervous system (CNS) tumor classification. The 2016 world health organization …
central nervous system (CNS) tumor classification. The 2016 world health organization …
[HTML][HTML] The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient …
S Karimi, JA Zuccato, Y Mamatjan, S Mansouri… - Clinical …, 2019 - Springer
Background Molecular signatures are being increasingly incorporated into cancer
classification systems. DNA methylation-based central nervous system (CNS) tumor …
classification systems. DNA methylation-based central nervous system (CNS) tumor …
Methylation classifiers: Brain tumors, sarcomas, and what's next
C Koelsche, A von Deimling - Genes, Chromosomes and …, 2022 - Wiley Online Library
Tumor classification has evolved over the last decades with technical progress contributing
much to our current concepts. Among diagnostic hallmarks, novelties were immunostaining …
much to our current concepts. Among diagnostic hallmarks, novelties were immunostaining …
Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes
Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive
surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and …
surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and …
[HTML][HTML] Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology
D Sturm, D Capper, F Andreiuolo, M Gessi… - Nature medicine, 2023 - nature.com
The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
DNA methylation profiling: an emerging paradigm for cancer diagnosis
A Papanicolau-Sengos, K Aldape - Annual Review of Pathology …, 2022 - annualreviews.org
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
Glioblastoma is characterized by widespread genetic and transcriptional heterogeneity, yet
little is known about the role of the epigenome in glioblastoma disease progression. Here …
little is known about the role of the epigenome in glioblastoma disease progression. Here …
Impact of the methylation classifier and ancillary methods on CNS tumor diagnostics
Z Wu, Z Abdullaev, D Pratt, HJ Chung… - Neuro …, 2022 - academic.oup.com
Background Accurate CNS tumor diagnosis can be challenging, and methylation profiling
can serve as an adjunct to classify diagnostically difficult cases. Methods An integrated …
can serve as an adjunct to classify diagnostically difficult cases. Methods An integrated …