Objective To investigate the potential for a causal effect of age at puberty on multiple
sclerosis (MS) susceptibility using a mendelian randomization (MR) approach. Methods We …

Cranial growth and development is a complex process which affects the closely related traits
of head circumference (HC) and intracranial volume (ICV). The underlying genetic …

The amount of genetic variation discovered in human populations is growing rapidly leading
to challenging computational tasks, such as variant calling. Standard methods for …

Optic nerve head morphology is affected by several retinal diseases. We measured the
vertical optic disc diameter (DD) of the UK Biobank (UKBB) cohort (N= 67 040) and …

Human population isolates provide a snapshot of the impact of historical demographic
processes on population genetics. Such data facilitate studies of the functional impact of rare …

Abstract Type 2 diabetes (T2D) mellitus is a common complex disease that currently affects
more than 400 million people worldwide and has become a global health problem. High …

Tremendous progress has been made in the genetic elucidation of obesity over the past two
decades, driven largely by technological, methodological and organizational innovations …

Here we ask the question “How much information do epigenomic datasets provide about
human genomic function?” We consider nine epigenomic features across 115 cell types and …

Atypical femoral fractures (AFFs) are uncommon and often related to prolonged
bisphosphonate (BP) treatment. Isolated cases have been linked to mutations of tissue …

Urine dipstick tests are widely used in routine medical care to diagnose kidney and urinary
tract and metabolic diseases. Several environmental factors are known to affect the test …