免疫检查点抑制剂(immune checkpoint inhibitors, ICI) 在多种晚期实体瘤治疗中取得了较好的
临床疗效, 其中包括结直肠癌. 但是大多数的肿瘤患者对ICI 的客观反应率(objective response …

Background: colorectal cancer (CRC) is a major cause of cancer-related death worldwide. In
recent years, targeting the programed cell death (PD-1)/programed cell death-1 ligand (PD …

Background The association between the expression of programmed cell death 1 (PD-1) or
its ligand [programmed cell death ligand-1 (PD-L1)] and colorectal cancer (CRC) survival …

It is unknown as to how liver metastases are correlated with host immune status in colorectal
cancer. In this study, we found that IL6, a proinflammatory cytokine produced in tumor …

Background: The programmed death-ligand 1 (PD-L1) pathway inhibits T-cell receptor-
mediated production of IL-2 and T-cell proliferation and plays an important role in the …

Kostimulatorische Signalwege spielen beim Zustandekommen einer T-Zell-gebundenen
Effektor-Immunantwort eine entscheidende Rolle. In dieser Arbeit wurde die Expression der …

Colorectal cancer is a common malignancy around the world, with an important mortality
rate among other malignancies. The cornerstone of treatment is curative surgery as 40% of …

Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence
suggests that CRC should be considered a heterogeneous disease, with multiple …

To the Editor: In current practice, the only definitive indication for neoadjuvant treatment for
locally advanced rectal adenocarcinoma remains to be the presence of T3/T4 tumor …

The immune system as a host defense system watches the cell growth and division,
eliminating cells with antigens different from those present in healthy cells. However, some …