The skull bones must grow in a coordinated, three‐dimensional manner to coalesce and
form the head and face. Mammalian skull bones have a dual embryonic origin from cranial …

Osteosarcomas are characterized by highly disrupted genomes. Although osteosarcomas
lack common fusions, we find evidence of many tumour specific gene-gene fusion …

Global gene deletion studies have established that Runt-related transcription factor-2
(Runx2) is essential during skeletogenesis for osteoblastic differentiation in both …

Dentin phosphoprotein (DPP) is a major component of the dentin matrix playing crucial role
in hydroxyapatite deposition during bone mineralization, making it a prime candidate for the …

Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells and are a major source of
innate TH2 cytokine secretion upon allergen exposure or parasitic-worm infection …

Abstract Polycystin-1 (PC1), encoded by the PKD1 gene that is mutated in the autosomal
dominant polycystic kidney disease, regulates a number of processes including bone …

Abstract Runt‐related transcription factor‐2 (Runx2) is essential for chondrocyte maturation
during cartilage development and embryonic mandibular condylar development. The …

Runt-related transcription factor 2 (Runx2), also known as core binding factor 1 (Cbfa1), is a
multifunctional transcription factor and an essential master gene controlling osteoblast …

Background The murine calvaria has several membrane bones with different tissue origins
(eg, neural crest‐derived frontal bone vs. mesoderm‐derived parietal bone). Neural crest …

Adenosine receptor activation has been investigated as a potential therapeutic approach to
heal bone. Bone has enhanced regenerative potential when influenced by either direct or …