[HTML][HTML] A deep learning framework to predict binding preference of RNA constituents on protein surface
Protein-RNA interaction plays important roles in post-transcriptional regulation. However,
the task of predicting these interactions given a protein structure is difficult. Here we show …
the task of predicting these interactions given a protein structure is difficult. Here we show …
hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles
H Fischl, J Neve, Z Wang, R Patel, A Louey… - Nucleic acids …, 2019 - academic.oup.com
Alternative cleavage and polyadenylation (APA) can occur at more than half of all human
genes, greatly enhancing the cellular repertoire of mRNA isoforms. As these isoforms can …
genes, greatly enhancing the cellular repertoire of mRNA isoforms. As these isoforms can …
[HTML][HTML] Combinatorial genetics reveals a scaling law for the effects of mutations on splicing
Despite a wealth of molecular knowledge, quantitative laws for accurate prediction of
biological phenomena remain rare. Alternative pre-mRNA splicing is an important regulated …
biological phenomena remain rare. Alternative pre-mRNA splicing is an important regulated …
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia
G Grigelioniene, HI Suzuki, F Taylan… - Nature medicine, 2019 - nature.com
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous
loss-of-function point mutations of miRNA genes are associated with several human …
loss-of-function point mutations of miRNA genes are associated with several human …
[HTML][HTML] Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
P Denichenko, M Mogilevsky, A Cléry, T Welte… - Nature …, 2019 - nature.com
Alternative splicing, a fundamental step in gene expression, is deregulated in many
diseases. Splicing factors (SFs), which regulate this process, are up-or down regulated or …
diseases. Splicing factors (SFs), which regulate this process, are up-or down regulated or …
[HTML][HTML] Modeling RNA-binding protein specificity in vivo by precisely registering protein-RNA crosslink sites
RNA-binding proteins (RBPs) regulate post-transcriptional gene expression by recognizing
short and degenerate sequence motifs in their target transcripts, but precisely defining their …
short and degenerate sequence motifs in their target transcripts, but precisely defining their …
[HTML][HTML] RegSNPs-intron: a computational framework for predicting pathogenic impact of intronic single nucleotide variants
Single nucleotide variants (SNVs) in intronic regions have yet to be systematically
investigated for their disease-causing potential. Using known pathogenic and neutral …
investigated for their disease-causing potential. Using known pathogenic and neutral …
Prediction of mRNA subcellular localization using deep recurrent neural networks
Z Yan, E Lécuyer, M Blanchette - Bioinformatics, 2019 - academic.oup.com
Motivation Messenger RNA subcellular localization mechanisms play a crucial role in post-
transcriptional gene regulation. This trafficking is mediated by trans-acting RNA-binding …
transcriptional gene regulation. This trafficking is mediated by trans-acting RNA-binding …
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
SG Hoge, Ö Almarsson, DD Hile, C Lawlor… - US Patent …, 2019 - Google Patents
2014-04-15 Assigned to MODERNA THERAPEUTICS, INC. reassignment MODERNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
CRIP: predicting circRNA–RBP-binding sites using a codon-based encoding and hybrid deep neural networks
Circular RNAs (circRNAs), with their crucial roles in gene regulation and disease
development, have become rising stars in the RNA world. To understand the regulatory …
development, have become rising stars in the RNA world. To understand the regulatory …