Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces

S Dunaway, A Rothaus, Y Zhang… - International Journal of …, 2019 - nature.com
Stem cells are of great interest to the scientific community due to their potential role in
regenerative and rejuvenative medicine. However, their role in the aging process and …

Sera/organ lysates of selected animals living in polluted environments exhibit cytotoxicity against cancer cell lines

S Jeyamogan, NA Khan, K Sagathevan… - Anti-Cancer Agents in …, 2019 - ingentaconnect.com
Background: Species of crocodiles and cockroaches can withstand high radiation, reside in
unsanitary conditions, thrive on germ-infested feed, and are exposed to heavy metals, yet …

Mitochondria inspire a lifestyle

P Kramer, P Bressan - Cellular and Molecular Basis of Mitochondrial …, 2019 - Springer
Tucked inside our cells, we animals (and plants, and fungi) carry mitochondria, minuscule
descendants of bacteria that invaded our common ancestor 2 billion years ago. This …

Contrasting Patterns of Rapid Molecular Evolution within the p53 Network across Mammal and Sauropsid Lineages

CN Passow, AM Bronikowski… - Genome Biology and …, 2019 - academic.oup.com
Cancer is a threat to multicellular organisms, yet the molecular evolution of pathways that
prevent the accumulation of genetic damage has been largely unexplored. The p53 network …

Tinbergean approach to clinical medicine

B Natterson-Horowitz - … into medical education: For maternal and …, 2019 - books.google.com
In 1973, two ornithologists and a bee biologist were awarded the Nobel Prize in Physiology
or Medicine. The decision to award a trio of animal behaviorists with this prize served not …

Dissecting trait variation across species barriers

CV Weiss, RB Brem - Trends in ecology & evolution, 2019 - cell.com
Dissecting the basis of naturally occurring trait variation is one of the central goals of modern
genetics. For eukaryotes, classic methods for this purpose rely on screens of recombinants …

Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis

X Li, V Caval, S Wain-Hobson, JP Vartanian - Scientific reports, 2019 - nature.com
The incidence of developing cancer should increase with the body mass, yet is not the case,
a conundrum referred to as Peto's paradox. Elephants have a lower incidence of cancer …

Translocation of promoter-conserved hatching enzyme genes with intron-loss provides a new insight in the role of retrocopy during teleostean evolution

T Nagasawa, M Kawaguchi, T Yano, S Isoyama… - Scientific Reports, 2019 - nature.com
The hatcing enzyme gene (HE) encodes a protease that is indispensable for the hatching
process and is conserved during vertebrate evolution. During teleostean evolution, it is …

Sex differences in cancer risk and survival

C Radkiewicz - 2019 - search.proquest.com
Aim: The objective of study I was to delineate and quantify sex differences in cancer risk and
survival together with assessing the potential gain achieved by eliminating the excess …

Integration of Evolutionary Theory into Cancer Biology and Caspase Signaling

RD Grinshpon, AC Clark - Unravelling Cancer Signaling Pathways: A …, 2019 - Springer
The caspase family of cysteine proteases consists of evolutionarily ancient regulators of the
programmed cell death (PCD) cascade known as apoptosis. Indeed, homologous caspase …