Fibroblast growth factor 21 in chronic kidney disease

PGA Suassuna, RB de Paula, H Sanders-Pinheiro… - Journal of …, 2019 - Springer
Abstract Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF family that
acts as a metabolic regulator of both glucose and lipid metabolism. Similar to fibroblast …

[HTML][HTML] The EPO-FGF23 signaling pathway in erythroid progenitor cells: opening a new area of research

AJ Van Vuren, CAJM Gaillard, MF Eisenga… - Frontiers in …, 2019 - frontiersin.org
We provide an overview of the evidence for an erythropoietin-fibroblast growth factor 23
(FGF23) signaling pathway directly influencing erythroid cells in the bone marrow. We …

[HTML][HTML] Skeletal mineralization: mechanisms and diseases

T Michigami - Annals of Pediatric Endocrinology & …, 2019 - synapse.koreamed.org
Skeletal mineralization is initiated in matrix vesicles (MVs), the small extracellular vesicles
derived from osteoblasts and chondrocytes. Calcium and inorganic phosphate (Pi) taken up …

Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease

X Su, Y Kong, D Peng - Clinica Chimica Acta, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in
several developed countries, ranging from simple non-alcoholic fatty liver (NAFL) to non …

αKlotho–FGF23 interactions and their role in kidney disease: a molecular insight

ER Smith, SG Holt, TD Hewitson - Cellular and Molecular Life Sciences, 2019 - Springer
Following the serendipitous discovery of the ageing suppressor, αKlotho (αKl), several
decades ago, a growing body of evidence has defined a pivotal role for its various forms in …

A review of fibroblast growth factor 21 in diabetic cardiomyopathy

X Zhang, L Yang, X Xu, F Tang, P Yi, B Qiu, Y Hao - Heart Failure Reviews, 2019 - Springer
Abstract FGF21 (fibroblast growth factor 21) is a regulator of metabolism and performs an
important role in glucose and lipid metabolism and the maintenance of energy balance …

Maresin 1 regulates hepatic FGF21 in diet‐induced obese mice and in cultured hepatocytes

L Martínez‐Fernández… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope To study the effects of Maresin 1 (MaR1), a docosahexaenoic‐acid‐derived lipid
mediator, on fibroblast growth factor 21 (FGF21) production and to characterize the tissue …

Fibroblast growth factor 21 ameliorates pancreatic fibrogenesis via regulating polarization of macrophages

N Wang, T Zhao, S Li, Y Li, Y Wang, D Li… - Experimental cell …, 2019 - Elsevier
Chronic pancreatitis (CP) is a progressive, irreversible inflammatory and fibrotic disease.
The characteristics of this disease are progressive inflammation, acinar atrophy and fibrosis …

Implications of fibroblast growth factors (FGFs) in cancer: from prognostic to therapeutic applications

H Dianat-Moghadam… - Current Drug Targets, 2019 - ingentaconnect.com
Fibroblast growth factors (FGFs) are pleiotropic molecules exerting autocrine, intracrine and
paracrine functions via activating four tyrosine kinase FGF receptors (FGFR), which further …

[HTML][HTML] AG protein–coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23

Q He, LT Shumate, J Matthias, C Aydin, MN Wein… - JCI insight, 2019 - ncbi.nlm.nih.gov
Dysregulated actions of bone-derived phosphaturic hormone fibroblast growth factor 23
(FGF23) result in several inherited diseases, such as X-linked hypophosphatemia (XLH) …