Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases
L Zhao, J Niu, H Lin, J Zhao, Y Liu, Z Song, C Xiang… - …, 2019 - thelancet.com
Background The development of a clinically useful fibroblast growth factor 21 (FGF21)
hormone has been impeded by its inherent instability and weak FGF receptor (FGFR) …
hormone has been impeded by its inherent instability and weak FGF receptor (FGFR) …
The enterokine fibroblast growth factor 15/19 in bile acid metabolism
M Cariello, M Piglionica, RM Gadaleta… - Bile Acids and Their …, 2019 - Springer
The endocrine fibroblast growth factors (FGFs), FGF19, FGF21, and FGF23, play a key role
in whole-body homeostasis. In particular, FGF19 is a postprandial hormone regulating …
in whole-body homeostasis. In particular, FGF19 is a postprandial hormone regulating …
Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia …
M Zarei, E Pujol, T Quesada‐López… - British journal of …, 2019 - Wiley Online Library
Background and Purpose FGF21 has emerged as a therapeutic strategy for treating type 2
diabetes mellitus due to its antidiabetic effects, and this has led to the development of long …
diabetes mellitus due to its antidiabetic effects, and this has led to the development of long …
The level of FGF 21 as a new risk factor for the occurrence of cardiometabolic disorders amongst the psoriatic patients
P Kiluk, A Baran, TW Kaminski, M Maciaszek… - Journal of clinical …, 2019 - mdpi.com
Fibroblast growth factors 21 and 23 are used as markers of cardiometabolic disorders which
are common comorbidities in psoriasis. The study aimed to evaluate the serum level of these …
are common comorbidities in psoriasis. The study aimed to evaluate the serum level of these …
Paracrine fibroblast growth factor 1 functions as potent therapeutic agent for intrahepatic cholestasis by downregulating synthesis of bile acid
H Lin, C Zhou, Y Hou, QI Li, G Qiao, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Endocrine fibroblast growth factor (FGF) 19 has been shown to be capable of maintaining
bile acid (BA) homeostasis and thus hold promise to be a potential therapeutic agent for …
bile acid (BA) homeostasis and thus hold promise to be a potential therapeutic agent for …
Increased levels of circulating fibroblast growth factor 21 in children with Kawasaki disease
Y Peng, Q Pei, S Feng, Y Su, R Liu, Q Yi… - Clinical and Experimental …, 2019 - Springer
The purpose of this study was to examine the serum levels of fibroblast growth factor 21
(FGF21) in children with acute Kawasaki disease (KD) and to investigate its relationship with …
(FGF21) in children with acute Kawasaki disease (KD) and to investigate its relationship with …
慢性肾脏病骨质疏松发病机制的研究进展
左彦波， 贾娟， 王红杰 - 医学研究与教育, 2019 - yxyjyjy.hbu.edu.cn
骨质疏松(osteoporosis, OP) 是慢性肾脏病(chronic kidney disease, CKD)
患者骨代谢紊乱常见的并发症之一, 是导致CKD 患者脆性骨折最主要的骨代谢性疾病 …
患者骨代谢紊乱常见的并发症之一, 是导致CKD 患者脆性骨折最主要的骨代谢性疾病 …
Identification of a crucial amino acid responsible for the loss of specifying FGFR1–KLB affinity of the iodinated FGF21
W Luo, XM Lin, TX Wang, JL Cai… - Journal of Cellular …, 2019 - Wiley Online Library
Previous studies suggest that specific binding to the complex consisting of fibroblast growth
factor receptor‐1 (FGFR1) and the coreceptor beta‐Klotho (KLB) is the premise for human …
factor receptor‐1 (FGFR1) and the coreceptor beta‐Klotho (KLB) is the premise for human …
Studies on the regulation of the phosphaturic hormone fibroblast growth factor 23 (FGF23)
L Bär - 2019 - repo.bibliothek.uni-halle.de
Fibroblast Growth Factor 23 (FGF23) is a bone-derived hormone that regulates blood levels
of phosphate and active vitamin D. In various human diseases, such as kidney or …
of phosphate and active vitamin D. In various human diseases, such as kidney or …