Disruptions in brain serotonin (5-hydroxytryptamine, 5-HT) signaling pathways have been
associated with etiology and pathogenesis of various neuropsychiatric disorders, but …

Several lines of evidence implicate a dysregulation of tryptophan hydroxylase (TPH)-
dependent serotonin (5-HT) synthesis in emotional behaviour and stress, and point to its …

Abstract Brain serotonin (5-HT) system dysfunction is implicated in depressive disorders and
acute depletion of 5-HT precursor tryptophan has frequently been used to model the …

Background The amygdaloid nuclei are involved in expression of anxiety and fear
responses. Malfunctioning of these nuclear complexes may be due in part to dysregulation …

Anxiety disorders represent one of the most prevalent mental disorders in today's society
and early adversity has been identified as major contributor to anxiety-related pathologies …

Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological
mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in …

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic
monoamine serotonin (5-hydroxytryptamine, 5-HT). Two existing TPH isoforms are …

Serotonin (5-HT) is a major neurotransmitter in the brain biosynthesis of which is initiated by
tryptophan hydroxylase 2 (TPH2). Polymorphisms in the TPH2 gene are suggested as risk …

Probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-HT, serotonin)
deficiency hypothesis. Accordingly, anomalies in putative 5-HT biomarkers have repeatedly …

Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-
hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different …