Objective To provide a review on the current use of antimicrobials with a discussion on the
pharmacokinetic and pharmacodynamic profiles of antimicrobials in critically ill patients, the …

Problem–The need for immediate, effective antimicrobial therapy in the critical care patient
must be tempered by approaches which simultaneously minimize emergence of …

Objective To appraise the evidence behind the Surviving Sepsis Campaign Guidelines on
antimicrobial therapy in sepsis and evaluate relevant literature in small animal veterinary …

Objective: To review the human and companion animal veterinary literature on nosocomial
infections and antimicrobial drug resistance as they pertain to the critically ill patient. Data …

In critically ill patients, a good outcome of an infection episode often requires early institution
of appropriate antimicrobial therapy. The choice of one specific antimicrobial agent or …

SMALL ANIMAL PRACTICE prudent to pursue the same path. We have further to go. The
age of using antimicrobials for lack of a better therapeutic option, with the belief that the …

For appropriate antibiotic therapy and selection, the clinician must be familiar with
pharmacodynamic concepts that integrate an antibiotic's microbiologic activity …

To better comprehend the antibiotic recommendations in this article, the reader should be
cognizant of a number of clinical, microbiologic, pharmacologic, and epidemiologic …

The public health community is increasingly concerned about the emergence of untreatable
diseases due to infections caused by resistant pathogenic bacteria. Increasing the dose can …

Critically ill patients with severe infections often have altered pharmacokinetic and
pharmacodynamic variables that lead to challenging treatment decisions. These altered …