Atypical femoral fractures (AFFs) are uncommon and often related to prolonged
bisphosphonate (BP) treatment. Isolated cases have been linked to mutations of tissue …

Atypical femoral fractures (AFFs) are a rare but potentially devastating event, often but not
always linked to bisphosphonate (BP) therapy. The pathogenic mechanisms underlying …

Osteoporosis is the most common metabolic bone disorder and nitrogen-containing
bisphosphonates (BP) are a first line treatment for it. Yet, atypical femoral fractures (AFF), a …

Background Case reports have linked adult hypophosphatasia as a possible cause of
atypical femur fractures (AFF) associated with bisphosphonate use. Adult hypophosphatasia …

Hypophosphatasia (HPP) is a rare genetic disorder characterized by low serum alkaline
phosphatase (ALP), its manifestations may include atypical femoral fractures (AFF) …

Abstract Purpose of Review Atypical femur fractures (AFFs) are rare subtrochanteric or
diaphyseal fractures regarded as side effects of bisphosphonates (BPs), possibly with a …

Atypical femoral fractures (AFFs) are uncommon and have been associated particularly with
long term antiresorptive therapy, including bisphosphonates. Although the pathogenesis of …

This study explores the genetic factors associated with atypical femoral fractures (AFF), rare
fractures associated with prolonged anti-resorptive therapy. AFF are fragility fractures that …

Atypical femoral fractures (AFF) are rare fragility fractures in the subtrocantheric or diaphysis
femoral region associated with long-term bisphosphonate (BP) treatment. The etiology of …

Atypical femoral fracture is a well-documented adverse reaction to bisphosphonates. It is
strongly related to duration of bisphosphonate use, and the risk declines rapidly after drug …