α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress

M Baeeri, H Bahadar, M Rahimifard… - Pharmacological …, 2019 - Elsevier
Senescence is a process characterized by an irreversible growth arrest in cells and induced
by oxidative stress. In the current study, anti-aging potential of a well-known antioxidant, α …

Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes

M Rahimifard, M Navaei-Nigjeh, M Baeeri… - Molecular and cellular …, 2015 - Springer
The naturally antioxidant and coenzyme, alpha-lipoic acid (α-LA), has gained considerable
attention regarding different functions and therapeutically effective in treating oxidative …

(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines

MNA Kamarudin, NA Mohd Raflee… - Drug design …, 2014 - Taylor & Francis
Alpha-lipoic acid, a potent antioxidant with multifarious pharmacological benefits has been
reported to be neuroprotective in several neuronal models and used to treat neurological …

Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging

M Baeeri, S Mohammadi-Nejad, M Rahimifard… - Molecular and Cellular …, 2018 - Springer
Aging is a natural process in living organisms that is defined by some molecular and cellular
changes with time. Various causes such as mitochondrial DNA aberrations, aggregation of …

Effect of alpha‐lipoic acid supplementation on markers of protein oxidation in post‐mitotic tissues of ageing rat

R Kayali, U Çakatay, T Akçay… - Cell Biochemistry and …, 2006 - Wiley Online Library
In the present study, we investigated whether dl‐α‐lipoic acid (LA) supplementation could
have prooxidant or antioxidant effects on oxidative protein damage parameters such as …

Immunomodulatory effect of DL-α-lipoic acid in aged rats

A Palaniyappan, R Alphonse - Experimental gerontology, 2011 - Elsevier
Senescence is the result of an imbalance between free radical production and antioxidant
defenses, with concomitant oxidative stress and age-dependent functional decline. This …

Increased ROS generation and p53 activation in α-lipoic acid-induced apoptosis of hepatoma cells

G Simbula, A Columbano, GM Ledda-Columbano… - Apoptosis, 2007 - Springer
Abstract α-lipoic acid (α-LA) is an antioxidant used for the treatment of a variety of diseases,
including liver cirrhosis, heavy metal poisoining, and diabetic polyneuropathy. In addition to …

Effect of DL-α-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats

P Arivazhagan, T Thilakavathy, K Ramanathan… - The Journal of …, 2002 - Elsevier
Free radicals have been implicated in the development of many acute and chronic diseases
and in conditions involving brain or neurological tissue. The primary genetic material is …

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

S Momtaz, M Baeeri, M Rahimifard… - Journal of cellular …, 2019 - Wiley Online Library
Aging contributes to an increased risk of developing a number of neurodegenerative and
chronic disorders, predominantly related to oxidative stress (OS) and defects in the …

Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy

E Selvakumar, T Hsieh - Journal of Hematology & Oncology, 2008 - Springer
Background Lipoic acid (LA), a potent antioxidant, has been used as a dietary supplement to
prevent and treat many diseases, including stroke, diabetes, neurodegenerative and hepatic …