The current immunosuppressive protocols used in transplant recipients have improved short-
term outcomes, but long-term allograft failure remains an important clinical problem. Greater …

The mechanism of rejection in solid organ transplantation is influenced by the initial
inflammatory response and subsequent adaptive allo-immune response, both of which have …

The complement cascade, traditionally considered to be relevant to transplantation only as
an effector mechanism of antibody-initiated allograft injury, is now understood to damage the …

Increasing evidence indicates an integral role for the complement system in the deleterious
inflammatory reactions that occur during critical phases of the transplantation process, such …

Kidney transplantation is a life-saving strategy for patients with end-stage renal disease.
Although progress has been made in the field of transplantation medicine in recent decades …

The complement cascade is a major contributor to the innate immune response. It has now
been well accepted that complement plays a critical role in hyperacute rejection and acute …

Complement has evolved as the first line of defence against pathogens, employing well
defined effector mechanisms to rapidly remove infectious material. However, complement …

In transplantation, activation of complement has largely been equated to antibody-mediated
rejection, but complement is also important in recognition of apoptotic and necrotic cells as …

Kidney transplantation is the therapy of choice for patients who suffer from end-stage renal
diseases. Despite improvements in surgical techniques and immunosuppressive treatments …

After decades of neglect, complement has been rediscovered as a potent mediator and
diagnostic indicator of inflammation and rejection in organ transplants. In part, this reflects a …