VEGF (vascular endothelial growth factor) functionalized magnetic beads in a microfluidic device to improve the angiogenic balance in preeclampsia

L Trapiella-Alfonso, L Alexandre, C Fraichard… - …, 2019 - Am Heart Assoc
Preeclampsia is a hypertensive pregnancy disease associated with a massive increase in
sFlt-1 (soluble form of the vascular endothelial growth factor 1) in the maternal circulation …

Magnetic blood purification‐based soluble fms‐like tyrosine kinase‐1 removal in comparison with dextran sulfate apheresis and therapeutic plasma exchange

T Rduch, N Arn, J Kinkel, T Fischer, I Binet… - Artificial …, 2023 - Wiley Online Library
Background Preeclampsia remains one of the most serious complications of pregnancy.
Effective therapies are yet to be developed. Recent research has identified an imbalance of …

Affinity-enhanced multimeric VEGF (vascular endothelial growth factor) and PlGF (placental growth factor) variants for specific adsorption of sFlt-1 to restore …

M Matin, M Mörgelin, J Stetefeld, B Schermer… - …, 2020 - Am Heart Assoc
Preeclampsia is a potentially life-threatening multisystem disease affecting 4% to 8% of
pregnant women after the 20th week of gestation. An excess of placental expressed …

Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia

R Thadhani, T Kisner, H Hagmann, V Bossung… - Circulation, 2011 - Am Heart Assoc
Background—Targeted therapies to stabilize the clinical manifestations and prolong
pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an …

A Maternally Sequestered, Biopolymer‐Stabilized Vascular Endothelial Growth Factor (VEGF) Chimera for Treatment of Preeclampsia

OC Logue, F Mahdi, H Chapman… - Journal of the …, 2017 - Am Heart Assoc
Background Preeclampsia is a hypertensive syndrome that complicates 3% to 5% of
pregnancies in the United States. Preeclampsia originates from an improperly vascularized …

Apheresis to treat preeclampsia: insights, opportunities and challenges

TR Easterling - Journal of the American Society of Nephrology, 2016 - journals.lww.com
J Am Soc Nephrol 27: 657–665, 2016 Editorials 663 www. jasn. org EDITORIALS and
mortality. The general approach of aggressive antenatal surveillance, diagnosis, and …

[HTML][HTML] Treatment of very preterm preeclampsia via heparin-mediated extracorporeal LDL-precipitation (HELP) apheresis: The Freiburg preeclampsia HELP …

K Winkler, C Contini, B König, B Krumrey, G Pütz… - Pregnancy …, 2018 - Elsevier
Abstract Objective: Soluble Fms-like tyrosine kinase-1 (sFlt-1) is thought to be causative in
the pathogenesis of preeclampsia (PE) and specific removal of sFlt-1 via dextran sulfate …

Case of soluble fms‐like tyrosine kinase 1 apheresis in severe pre‐eclampsia developed at 15 weeks' gestation

B Nakakita, H Mogami, E Kondoh… - Journal of Obstetrics …, 2015 - Wiley Online Library
Soluble fms‐like tyrosine kinase‐1 (sFlt1), a circulating vascular endothelial growth factor
receptor 1 antagonist, is associated with the pathogenesis of pre‐eclampsia. Extracorporeal …

Removal of soluble fms-like tyrosine kinase-1 by dextran sulfate apheresis in preeclampsia

R Thadhani, H Hagmann… - Journal of the …, 2016 - journals.lww.com
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-
1 (sFlt-1) is an antiangiogenic protein believed to mediate the signs and symptoms of …

Heparin-mediated extracorporeal low density lipoprotein precipitation as a possible therapeutic approach in preeclampsia

Y Wang, AK Walli, A Schulze, F Blessing… - … and Apheresis Science, 2006 - Elsevier
Preeclampsia is a pregnancy-related hypertensive disease resulting in substantial maternal
and neonatal morbidity and mortality. Until today there is no satisfactory treatment to stop …