The benefits of physical activity in cardiovascular diseases have long been appreciated.
However, the molecular mechanisms that trigger and sustain the cardiac benefits of exercise …

Metabolic reprogramming is critical in the onset of pressure overload–induced cardiac
remodeling. Our study reveals that proline dehydrogenase (PRODH), the key enzyme in …

Background. Coronary heart disease is currently the leading cause of death in humans. Its
poor prognosis and high mortality are associated with myocardial ischemia, which leads to …

The cardiac benefits of exercise have been recognized for centuries. Studies have
undisputedly shown that regular exercise is beneficial for the cardiovascular system in …

Background Dilated cardiomyopathy (DCM) is a public health problem with no available
curative treatment, and mitochondrial dysfunction plays a critical role in its development. The …

Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple
stress pathways. Because of the roles of PRODH/POX in signaling, and its shared …

Hallmark features of systolic heart failure are reduced contractility and impaired metabolic
flexibility of the myocardium. Cardiomyocytes (CMs) with elevated deoxy ATP (dATP) via …

Despite advanced treatments for heart failure (HF), morbidity, and mortality rates remain
high. 1 Understanding the gene regulatory networks and signaling pathways involved in …

Current management of heart failure (HF) is centred on modulating the progression of
symptoms and severity of left ventricular dysfunction. However, specific understandings of …

Dilated cardiomyopathy (DCM) is the most common cause of heart failure, with a complex
aetiology involving multiple cell types. We aimed to detect cell-specific transcriptomic …