Vasopressin in the amelioration of social functioning in autism spectrum disorder

MA Hendaus, FA Jomha, AH Alhammadi - Journal of Clinical Medicine, 2019 - mdpi.com
Autism spectrum disorder (ASD) is a developmental disability described by diagnostic
criteria that comprise deficits in social communication and the existence of repetitive …

A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism

KJ Parker, O Oztan, RA Libove, N Mohsin… - Science translational …, 2019 - science.org
The social impairments of autism spectrum disorder (ASD) have a major impact on quality of
life, yet there are no medications that effectively treat these core social behavior deficits …

A single dose, randomized, controlled proof-of-mechanism study of a novel vasopressin 1a receptor antagonist (RG7713) in high-functioning adults with autism …

D Umbricht, M del Valle Rubido, E Hollander… - …, 2017 - nature.com
The core symptoms of autism spectrum disorder (ASD) include impaired social
communication, repetitive behaviors, and restricted interests. No effective pharmacotherapy …

Vasopressin as possible treatment option in autism spectrum disorder

K László, D Vörös, P Correia, CL Fazekas, B Török… - Biomedicines, 2023 - mdpi.com
Autism spectrum disorder (ASD) is rather common, presenting with prevalent early problems
in social communication and accompanied by repetitive behavior. As vasopressin was …

Vasopressin deficiency: a hypothesized driver of both social impairment and fluid imbalance in autism spectrum disorder

L Clarke, N Gesundheit, EH Sherr, AY Hardan… - Molecular …, 2024 - nature.com
Scientific naming conventions are often idiosyncratic. For example, biological processes
have acquired names after a physician who described a syndrome (Alois Alzheimer), the …

Modulation of the vasopressin system for the treatment of CNS diseases.

T Ryckmans - Current opinion in drug discovery & development, 2010 - europepmc.org
Vasopressin (also known as arginine vasopressin [AVP]) is a small cyclic peptide that acts at
the V1a, V1b and V2 GPCRs to regulate a wide range of physiological functions, including …

A phase 2 clinical trial of a vasopressin V1a receptor antagonist shows improved adaptive behaviors in men with autism spectrum disorder

F Bolognani, M del Valle Rubido… - Science translational …, 2019 - science.org
There are no approved pharmacological therapies to address the core symptoms of autism
spectrum disorder (ASD), namely, persistent deficits in social communication and social …

The role of the oxytocin/arginine vasopressin system in animal models of autism spectrum disorder

R Zhang, XJ Xu, HF Zhang, SP Han, JS Han - Translational Anatomy and …, 2017 - Springer
The nonapeptides oxytocin (OXT) and arginine vasopressin (AVP) are two key mediators in
regulating various aspects of mammalian social behaviours. There are several lines of …

The contribution of oxytocin and vasopressin to mammalian social behavior: potential role in autism spectrum disorder

H Harony, S Wagner - Neurosignals, 2011 - karger.com
Oxytocin (OT) and arginine-vasopressin (AVP) are 2 peptides that are produced in the brain
and released via the pituitary gland to the peripheral blood, where they have diverse …

Oxytocin, vasopressin, and social behavior: from neural circuits to clinical opportunities

N Rigney, GJ de Vries, A Petrulis, LJ Young - Endocrinology, 2022 - academic.oup.com
Oxytocin and vasopressin are peptide hormones secreted from the pituitary that are well
known for their peripheral endocrine effects on childbirth/nursing and blood pressure/urine …