Abstract β-2 Microglobulin (β2M) is a molecular chaperone for the major histocompatibility
class I (MHC I) complex, hemochromatosis factor protein (HFE), and the neonatal Fc …

Platelets have central roles in both immune responses and development. Stimulated
platelets express leukocyte adhesion molecules and release numerous immune modulatory …

Rationale: Circulating monocytes can have proinflammatory or proreparative phenotypes.
The endogenous signaling molecules and pathways that regulate monocyte polarization in …

Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after
myocardial infarction (MI); however, how these factors crosstalk with other cell types …

Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large,
polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone …

Abstract β2-Microglobulin (β2m) is a chaperone of major histocompatibility complex (MHC)
class I (–like) molecules that play a central role in antigen presentation, immunoglobulin …

Platelets are highly reactive cell fragments that adhere to exposed extracellular matrix
(ECM) and prevent excessive blood loss by forming clots. Paradoxically, megakaryocytes …

In humans, blood Classical CD14+ monocytes contribute to host defense by secreting large
amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation …

Rationale: Wound healing after myocardial infarction involves a highly regulated
inflammatory response that is initiated by the appearance of neutrophils to clear out dead …

Background Myocardial injury is a major cause of myocardial remodeling. Macrophages are
important in cardiac repair as a result of their interactions with fibroblasts. As regulatory …