CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell
receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human …

Human T cell autoreactivity toward lipid antigens presented by CD1 proteins can manifest in
numerous diseases, including psoriasis, contact hypersensitivities, and allergies. However …

Plasma membranes of eukaryotic cells are not uniform, possessing distinct cholesterol-and
sphingolipid-rich lipid raft microdomains which constitute critical sites for signal transduction …

CD1 proteins have been conserved throughout mammalian evolution and function to
present lipid antigens to T cells. Crystal structures of CD1‐lipid complexes show that CD1 …

Highlights•Human CD1-autoreactive T cells are common and can mediate autoimmunity.•T
cell receptors can bind directly to CD1 without contacting bound lipid.•Lipids can hide buried …

The CD1 family of antigen-presenting molecules adopt a major histocompatibility complex
class I (MHC-I) fold. Whereas MHC molecules present peptides, the CD1 family has evolved …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

A central paradigm in αβ T cell–mediated immunity is the simultaneous co-recognition of
antigens and antigen-presenting molecules by the αβ T cell antigen receptor (TCR). CD1a …

CD2 mediates T cell adhesion via its ectodomain and signal transduction utilizing its 117-
amino acid cytoplasmic tail. Here we show that a significant fraction of human CD2 …

T lymphocytes are the cells of the immune system that may recognize glycolipids as
antigens. T cells recognize lipids associated with the non-polymorphic molecules of the CD1 …