Topoisomerases are DNA processing enzymes that relieve supercoiling (torsional strain) in
DNA, are necessary for normal cellular division, and act by nicking (and then religating) …

Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

DNA topoisomerases are the targets of important anticancer and antibacterial drugs.
Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines …

Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause
cancer cell death by inducing DNA damage, which mechanism of action is also associated …

To resolve the topological problems that threaten the function and structural integrity of
nuclear and mitochondrial genomes and RNA molecules, human cells encode six different …

Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

DNA topoisomerases are a class of enzymes that alter the topology of DNA and are targets
of several anticancer drugs. Camptothecins (CPTs) are a relatively new family of compounds …

DNA topoisomerases (topos) are essential enzymes that regulate the topological state of
DNA during cellular processes such as replication, transcription, recombination, and …

To overcome chemical limitations of camptothecin (CPT), we report design, synthesis, and
validation of a quinoline-based novel class of topoisomerase 1 (Top1) inhibitors and …

Topoisomerase II (TOP2) poisons interfere with the breakage/reunion reaction of TOP2
resulting in DNA cleavage. In the current studies, we show that two different classes (ATP …