Background: Recent studies have identified that abnormal macrophage polarization has
critical roles in the pathogeneses of some autoimmune diseases, but evidence from systems …

The underlying mechanisms of macrophage polarization have been detected by genome-
wide transcriptome analysis in a variety of mammals. However, the transcriptome profile of …

Macrophages are key cell types of the innate immune system regulating host defense,
inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and …

Macrophages are key inflammatory immune cells that display dynamic phenotypes and
functions in response to their local microenvironment. Major advances have occurred in …

Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic
transition between M1 and M2 polarized phenotypes. The aim of the present study was to …

Background Macrophage polarization has a causal role in the pathogenesis and resolution
of various clinical diseases. DNA-binding transcription factors (TFs) have been identified as …

Macrophages are key players in human innate immunity that protect the organism from
pathologic agents, including infection and malignant cells. The spectrum of their functions …

Macrophages, key players in the innate immune system, showcase remarkable adaptability.
Derived from monocytes, these phagocytic cells excel in engulfing and digesting pathogens …

Growing evidence defines macrophages (Mφ) as plastic cells with wide-ranging states of
activation and expression of different markers that are time and location dependent. Distinct …

Noncoding regulatory variants play an important role in the genetics of complex traits.
Although quantitative trait locus (QTL) mapping is a powerful approach to identify these …