Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

DM Tufts, TM Hart, GF Chen… - Molecular …, 2019 - Wiley Online Library
Lyme borreliosis is caused by multiple species of the spirochete bacteria Borrelia
burgdorferi sensu lato. The spirochetes are transmitted by ticks to vertebrate hosts, including …

Enzootic origins for clinical manifestations of Lyme borreliosis

S Jahfari, A Krawczyk, EC Coipan, M Fonville… - Infection, Genetics and …, 2017 - Elsevier
Both early localized and late disseminated forms of Lyme borreliosis are caused by Borrelia
burgdorferi senso lato. Differentiating between the spirochetes that only cause localized skin …

The role of Borrelia burgdorferi outer surface proteins

MR Kenedy, TR Lenhart… - FEMS Immunology & …, 2012 - academic.oup.com
Human pathogenic spirochetes causing Lyme disease belong to the Borrelia burgdorferi
sensu lato complex. Borrelia burgdorferi organisms are extracellular pathogens transmitted …

Antigenic variation in Borrelia: relapsing fever and Lyme borreliosis

AG Barbour - Antigenic variation, 2003 - Elsevier
Publisher Summary Relapsing fever (RF) was the first recognized example of antigenic
variation. The typical pattern of illness that was followed by recovery and relapse attracted …

Insights into the biology of Borrelia burgdorferi gained through the application of molecular genetics

AM Groshong, JS Blevins - Advances in applied microbiology, 2014 - Elsevier
Borrelia burgdorferi, the vector-borne bacterium that causes Lyme disease, was first
identified in 1982. It is known that much of the pathology associated with Lyme borreliosis is …

Molecular and immunological analysis of a polymorphic periplasmic protein of Borrelia burgdorferi

WJ Simpson, ME Schrumpf, SF Hayes… - Journal of clinical …, 1991 - Am Soc Microbiol
Borrelia burgdorferi is the causative agent of Lyme disease, a tick-borne spirochetosis with a
worldwide prevalence. To assist the categorization and typing of fresh isolates from global …

Lyme borreliosis: host responses to Borrelia burgdorferi

A Szczepanski, JL Benach - Microbiological reviews, 1991 - Am Soc Microbiol
The chronic inflammatory condition that develops after infection by B. burgdorferi is a
complex process resulting from host responses to a limited number of organisms …

Borrelia pathogenesis research in the post-genomic and post-vaccine era

A Nordstrand, AG Barbour, S Bergström - Current opinion in microbiology, 2000 - Elsevier
In the two years after publication of the genome sequence of Borrelia burgdorferi and reports
on human field trials of a vaccine against Lyme borreliosis, there has been further progress …

Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi

PA Rosa, T Schwan, D Hogan - Molecular microbiology, 1992 - Wiley Online Library
Borrelia burgdorferi causes Lyme disease, a multisystem illness that can persist in humans
for many years. We describe recombination between homologous genes encoding the …

Cryptic and Exposed Invariable Regions of VlsE, the Variable Surface Antigen of Borrelia burgdorferisl

FT Liang, JM Nowling, MT Philipp - Journal of bacteriology, 2000 - Am Soc Microbiol
Borrelia burgdorferi, the Lyme disease spirochete, possesses a surface protein, VlsE, which
undergoes antigenic variation. VlsE contains two invariable domains and a variable one that …