Nitrogen mustards, a family of DNA alkylating agents, marked the start of cancer
pharmacotherapy. While traditionally characterized by their dose-limiting toxic effects …

Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …

Background & Objective: Nitrogen mustard derivatives form one of the major classes of anti-
cancer agents in USFDA approved drugs list. These are polyfunctional alkylating agents …

Cancer is considered one of the gruelling challenges and poses a grave health hazard
across the globe. According to the International Agency for Research on Cancer (IARC) …

The cancer tissue hypoxia regions are present with an acidic microenvironment that prevent
the intake of various components like drugs, nutrients, and other metabolites, encouraging …

Nitrogen mustards, an important class of drugs for cancer therapy, are known as DNA
alkylating agents. The nitrogen mustards are highly reactive and, as a consequence, lack of …

The long-term understanding of cancer growth is that it is a net result of uncontrolled
multiplication of cells that out paces the rate of natural cell death within the tumour mass …

Publisher Summary Nitrogen mustards were among the earliest drugs to be used for
systemic cancer treatment. An enormous amount of information has become available on …

Three novel H2O2‐activated aromatic nitrogen mustard prodrugs (6–8) are reported. These
compounds contain a DNA alkylating agent connected to a H2O2‐responsive trigger by …

As medicine advances, cancer is still among one of the major health problems, posing
significant threats to human health. New anticancer agents features with novel scaffolds …