Lung injury activates quiescent stem and progenitor cells to regenerate alveolar structures.
The sequence and coordination of transcriptional programs during this process has largely …

Lung epithelial regeneration after acute injury requires coordination cellular coordination to
pattern the morphologically complex alveolar gas exchange surface. During adult lung …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

Understanding the molecular and cellular processes involved in lung epithelial regeneration
may fuel the development of therapeutic approaches for lung diseases. We combine mouse …

Lung injury activates specialized adult epithelial progenitors to regenerate the epithelium.
Depending on the extent of injury, both remaining alveolar type II cells (AEC2s) and distal …

Many lung diseases result from a failure of efficient regeneration of damaged alveolar
epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace …

Alveolar epithelial type 2 cells (AEC2s) are the facultative progenitors responsible for
maintaining lung alveoli throughout life but are difficult to isolate from patients. Here, we …

Understanding differential lineage potential of orthologous stem cells across species can
shed light on human disease. Here, utilizing 3D organoids, single cell RNAseq, and …

Mechanisms of epithelial renewal in the alveolar compartment remain incompletely
understood. To this end, we aimed to characterize alveolar progenitors. Single-cell RNA …

Organ regeneration requires dynamic cell interactions to reestablish cell numbers and tissue
architecture. While we know the identity of progenitor cells that replace lost tissue, the …