Although the mucus layer is the first biological barrier encountered by inhaled drugs upon
their deposition in the upper airways, its potential impact on drug dissolution and absorption …

For drug delivery to the airways to be effective the protective mechanisms of the lung must
be overcome so that the drug can reach its site of action. Airway mucus is an integral part of …

The airway epithelium together with the mucus layer coating it forms a protective system that
efficiently filters and removes potentially harmful particles contained in inhaled air. The same …

During the process of inhalable formulation development a deep knowledge of the
physicochemical characteristics of the drug and formulation components and the biological …

Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

Background Pulmonary drug delivery is characterized by short onset times of the effects and
an increased therapeutic ratio compared to oral drug delivery. This delivery route can be …

The fate of inhaled particles after deposition onto the pulmonary mucosa is far from being
solved, in particular with respect to mucociliary clearance and mucus penetration. Due to the …

Inhalation drug delivery is an effective means for local and systemic delivery of conventional
drugs and biopharmaceuticals, in the treatment of pulmonary and non-pulmonary diseases …

The aim of this work was to compare three existing mucus-secreting airway cell lines for use
as models of the airways to study drug transport in the presence of mucus. Each cell line …

Introduction: Airway mucus gel layer serves as a key delivery barrier that limits the
performance of inhaled drug delivery nanoparticles. Conventional nanoparticles are readily …