Background Oxaliplatin (OXA) resistance is a main obstacle to the chemotherapy of
colorectal cancer (CRC). Epithelial-mesenchymal transition (EMT), which is mainly …

Resistance to oxaliplatin (OXA) is a complex process affecting the outcomes of metastatic
colorectal cancer (CRC) patients treated with this drug. De-regulation of the NF-κB signalling …

Background and purpose Colorectal cancer is a kind of gastrointestinal tumor with rising
morbidity and mortality. 5-fluorouracil is one of the most effective chemotherapy drugs for the …

The objective of this study was to investigate the effect and the mechanism by which
curcumin reverses irinotecan-induced chemotherapy resistance in colon cancer …

The aims of this study were to determine potency of oxaliplatin in combination with curcumin
in oxaliplatin‐resistant cell lines in vitro and to evaluate the efficacy of a novel curcumin …

Background. Oxaliplatin (L‐OHP) resistance is a major obstacle to the effective treatment of
colorectal cancer. The resistance mechanism (s) of colorectal tumors to L‐OHP may be …

Cisplatin resistance in colorectal cancer largely results from the colorectal cancer stem cells
which could be targeted to improve the efficacy of chemotherapy. MicroRNAs are possible …

Objective Colorectal cancer (CRC) is one of the most lethal and prevalent malignancies
world-wide. Currently, surgery, radiotherapy and chemotherapy are clinically applied as …

Objective Development of treatment resistance and adverse toxicity associated with
classical chemotherapeutic agents highlights the need for safer and effective therapeutic …

Objectives Chemoresistance development represents a major obstacle to the successful
treatment of colorectal cancer (CRC). The aim of this study was to elucidate the mechanism …