Background It is well known that after menopause women are exposed to a greater
cardiovascular risk, but the intracellular modifications are not properly described. The …

Two alkalinizing mechanisms coexist in cardiac myocytes to maintain intracellular pH:
sodium/bicarbonate cotransporter (electroneutral isoform NBCn1 and electrogenic isoform …

Abstract Aims Electroneutral (NBCn1) and electrogenic (NBCe1) isoforms of the Na+–
HCO3− cotransporter (NBC) coexist in the heart. We studied the expression and function of …

The role of the cardiac isoform of the electrogenic sodium-bicarbonate ion cotransporter
(NBCe1) in cardiac remodeling is not fully understood. The aim of this study was to assess …

Objective: Although it is believed that sodium-driven acid–base transport plays a central role
in the development of the reperfusion injury that follows cardiac ischemia, research to date …

BACKGROUND AND PURPOSE Na+/HCO3‐co‐transport (NBC) regulates intracellular pH
(pHi) in the heart. We have studied the electrogenic NBC isoform NBCe1 by examining the …

Cardiac tissue ischemia/hypoxia increases glycolysis and lactic acid accumulation in
cardiomyocytes, leading to intracellular metabolic acidosis. Sodium bicarbonate …

The sodium/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms in
the cardiomyocytes. It has been demonstrated the existence of at least two functional …

The contribution of sodium-dependent bicarbonate transport to intracellular pH (pHi)
regulation in vascular smooth muscle cells is controversial, partly because the molecular …

Abstract The Na+-HCO 3− cotransporter (NBC) plays a key role in intracellular pH (pH i)
regulation in normal ventricular muscle. However, the state of NBC in nonischemic …