Objective: To develop a pharmacokinetic-pharmacogenomic population model of morphine
in critically ill children with acute respiratory failure. Design: Prospective pharmacokinetic …

Objectives: To develop a pharmacokinetic-pharmacogenomic population model of
midazolam in critically ill children with primary respiratory failure. Design: Prospective …

A morphine plasma concentration/respiratory rate relationship has been described for both
adults and children although that of its metabolite, morphine-6-glucuronide, remains …

Titrating analgesic and sedative drugs in pediatric intensive care remains a challenge for
caregivers due to the lack of pharmacodynamic knowledge in this population. The aim of the …

Abstract Background and Objective Model validation procedures are crucial when models
are to be used to develop new dosing algorithms. In this study, the predictive performance of …

Abstract Next Challenge From the Variance in Individual Physiologically-Based
Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill …

Morphine is commonly used for analgesia in the neonatal intensive care unit (NICU) despite
having highly variable pharmacokinetics (PKs) between individual patients. The …

Abstract Background and Objectives From a previously validated paediatric population
pharmacokinetic model, it was derived that non-linear morphine maintenance doses of 5 …

BACKGROUND: Although morphine is used frequently to treat pain in the intensive care
unit, its pharmacokinetics has not been adequately quantified in critically ill patients. We …

Objectives To determine a) if serum morphine concentration changes during the first 3 hrs of
extracorporeal membrane oxygenation (ECMO); and b) if absorption of morphine onto the …