Guanosine, a guanine-based purine nucleoside, has been described as a neuromodulator
that exerts neuroprotective effects in animal and cellular ischemia models. However …

Mutagenesis of the human A3 adenosine receptor (AR) suggested that certain amino acid
residues contributed differently to ligand binding and activation processes. Here we …

The effect of denaturation and/or extraction of nonintegral membrane proteins by 7 m urea
on the binding of the antagonist [3H] cyclopentyl‐1, 3‐dipropylxanthine 8 dipropyl‐2, 3 ([3H] …

To provide insights into interactions between ligands and A2A adenosine receptors, site-
directed mutagenesis was used to test the roles of a glutamic acid residue in the first …

Adenosine is a signaling molecule, which, by activating its receptors, acts as an important
player after cerebral ischemia. Here, we review data in the literature describing A2BR …

Excitatory toxicity is still a hot topic in the study of ischemic stroke, and related research has
focused mainly on neurons. Adenosine is an important neuromodulator that is known as a …

Abstract A 2A and A 2B adenosine receptors (ARs) are closely related G protein-coupled
receptor subtypes, which represent important (potential) drug targets. Despite their almost …

Despite the identification of 2-amino-3-benzoylthiophenes (2A3BTs) as the first example of
small-molecule allosteric potentiators of agonist function at a G protein-coupled receptor …

Endogenous ligands of G protein-coupled receptors bind to orthosteric sites that are
topologically distinct from allosteric sites. Certain aminothiophenes such as (2-amino-4, 5 …

The aim of this paper was to check the possible interaction of two of the four purinergic P1
receptors, the A2A and the A3. Discovery of the A2A–A3 receptor complex was achieved by …