[HTML][HTML] Genome-wide mapping of nucleotide excision repair with XR-seq

J Hu, W Li, O Adebali, Y Yang, O Oztas, CP Selby… - Nature protocols, 2019 - nature.com
Nucleotide excision repair is a versatile mechanism to repair a variety of bulky DNA adducts.
We developed excision repair sequencing (XR-seq) to study nucleotide excision repair of …

In vitro DNA repair genomics using XR-seq with Escherichia coli and mammalian cell-free extracts

X Cao, C Kose, CP Selby… - Proceedings of the …, 2023 - National Acad Sciences
The XR-seq (eXcision Repair-sequencing) method has been extensively used to map
nucleotide excision repair genome-wide in organisms ranging from Escherichia coli to yeast …

[HTML][HTML] Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

J Hu, CP Selby, S Adar, O Adebali, A Sancar - Journal of Biological …, 2017 - ASBMB
Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this
repair system, the DNA damage is removed by concerted dual incisions bracketing the …

Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis

S Adar, J Hu, JD Lieb, A Sancar - Proceedings of the …, 2016 - National Acad Sciences
We recently developed a high-resolution genome-wide assay for mapping DNA excision
repair named eXcision Repair-sequencing (XR-seq) and have now used XR-seq to …

High resolution mapping of modified DNA nucleobases using excision repair enzymes

DS Bryan, M Ransom, B Adane, K York… - Genome …, 2014 - genome.cshlp.org
The incorporation and creation of modified nucleobases in DNA have profound effects on
genome function. We describe methods for mapping positions and local content of modified …

Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo [a] pyrene

W Li, J Hu, O Adebali, S Adar, Y Yang… - Proceedings of the …, 2017 - National Acad Sciences
Benzo [a] pyrene (BaP), a polycyclic aromatic hydrocarbon, is the major cause of lung
cancer. BaP forms covalent DNA adducts after metabolic activation and induces mutations …

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

J Hu, S Adar, CP Selby, JD Lieb… - Genes & …, 2015 - genesdev.cshlp.org
We developed a method for genome-wide mapping of DNA excision repair named XR-seq
(excision repair sequencing). Human nucleotide excision repair generates two incisions …

Nucleotide excision repair: from E. coli to man

C Petit, A Sancar - Biochimie, 1999 - Elsevier
Nucleotide excision repair is both awide spectrum'DNA repair pathway and the sole system
for repairing bulky damages such as UV lesions or benzo [a] pyrene adducts. The …

[HTML][HTML] Quantifying DNA double-strand breaks induced by site-specific endonucleases in living cells by ligation-mediated purification

C Chailleux, F Aymard, P Caron, V Daburon… - Nature protocols, 2014 - nature.com
Recent advances in our understanding of the management and repair of DNA double-strand
breaks (DSBs) rely on the study of targeted DSBs that have been induced in living cells by …

[HTML][HTML] Pervasive Transcription-coupled DNA repair in E. coli

B Martinez, BK Bharati, V Epshtein, E Nudler - Nature communications, 2022 - nature.com
Abstract Global Genomic Repair (GGR) and Transcription-Coupled Repair (TCR) have been
viewed, respectively, as major and minor sub-pathways of the nucleotide excision repair …