The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

In addition to storing and mobilizing energy, adipocytes secrete circulating factors to signal
to other tissues and coordinate energy metabolism. These functions can become disrupted …

Adiponectin and leptin are two adipokines secreted by white adipose tissue that regulate
insulin sensitivity. Previously we reported that adiponectin but not leptin release depends on …

Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

Adiponectin regulates energy homeostasis through the modulation of glucose and fatty acid
metabolism in peripheral tissues. However, its central effect on energy balance remains …

Adiponectin, first described in the mid-1990s, is one of the most widely studied adipokines to
date. Studies of its regulation, biogenesis and physiological effects have yielded great …

Adipose tissue performs complex metabolic and endocrine functions. This review will focus
on the recent literature on the biology and actions of three adipocyte hormones involved in …

Cardiovascular disease accounts for an overwhelming proportion of the morbidity and
mortality suffered by patients with obesity and type 2 diabetes mellitus, and recent work has …

In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …