Despite intensive research, no satisfactory therapeutic options have been found for aging
and age-related diseases. The British scientist Leslie Orgel stated that evolution is cleverer …

One of the challenges facing science/biology today is uncovering the molecular bases that
support and determine animal and human longevity. Nature, in offering a diversity of animal …

Available studies are consistent with the possibility that oxygen radicals endogenously
produced by mitochondria are causally involved in the determination of the rate of aging in …

Among several theories to explain the complicated process of human ageing, the
mitochondrial oxidative stress hypothesis has received recent attention. Considering that …

The main purpose of this article is to provide a critical overview of the currently available
evidence bearing on the validity of the oxidative stress hypothesis of aging, which postulates …

Plants and their corresponding botanical preparations have been used for centuries due to
their remarkable potential in both the treatment and prevention of oxidative stress-related …

Traditionally, the main mammalian models used in aging research have been mice and rats,
ie short-lived species that obviously lack effective maintenance mechanisms to keep their …

Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …

Identifying the mechanisms determining species-specific life spans is a central challenge in
understanding the biology of aging. Cellular stresses produce damage, that may accumulate …

Key mechanisms relating oxidative stress to longevity from an interespecies comparative
approach are reviewed. Long-lived animal species show low rates of reactive oxygen …