Bacteria control cell volume by coupling cell-surface expansion to dry-mass growth

ER Oldewurtel, Y Kitahara, B Cordier, G Özbaykal… - BioRxiv, 2019 - biorxiv.org
Cells exhibit a high degree of intracellular crowding. To control the level of crowding during
growth cells must increase their volumes in response to the accumulation of biomass. Using …

Robust surface-to-mass coupling and turgor-dependent cell width determine bacterial dry-mass density

ER Oldewurtel, Y Kitahara… - Proceedings of the …, 2021 - National Acad Sciences
During growth, cells must expand their cell volumes in coordination with biomass to control
the level of cytoplasmic macromolecular crowding. Dry-mass density, the average ratio of …

Precise regulation of the relative rates of surface area and volume synthesis in bacterial cells growing in dynamic environments

H Shi, Y Hu, PD Odermatt, CG Gonzalez… - Nature …, 2021 - nature.com
The steady-state size of bacterial cells correlates with nutrient-determined growth rate. Here,
we explore how rod-shaped bacterial cells regulate their morphology during rapid …

Surface area to volume ratio: a natural variable for bacterial morphogenesis

LK Harris, JA Theriot - Trends in microbiology, 2018 - cell.com
An immediately observable feature of bacteria is that cell size and shape are remarkably
constant and characteristic for a given species in a particular condition, but vary …

[PDF][PDF] Principles of bacterial cell-size determination revealed by cell-wall synthesis perturbations

C Tropini, TK Lee, J Hsin, SM Desmarais, T Ursell… - Cell reports, 2014 - cell.com
Although bacterial cell morphology is tightly controlled, the principles of size regulation
remain elusive. In Escherichia coli, perturbation of cell-wall synthesis often results in similar …

Cellular resource allocation strategies for cell size and shape control in bacteria

D Serbanescu, N Ojkic, S Banerjee - The FEBS journal, 2022 - Wiley Online Library
Bacteria are highly adaptive microorganisms that thrive in a wide range of growth conditions
via changes in cell morphologies and macromolecular composition. How bacterial …

Surface-to-volume scaling and aspect ratio preservation in rod-shaped bacteria

N Ojkic, D Serbanescu, S Banerjee - Elife, 2019 - elifesciences.org
Rod-shaped bacterial cells can readily adapt their lengths and widths in response to
environmental changes. While many recent studies have focused on the mechanisms …

[PDF][PDF] Bacterial cell shape control by nutrient-dependent synthesis of cell division inhibitors

N Ojkic, S Banerjee - Biophysical Journal, 2021 - cell.com
By analyzing cell size and shapes of the bacterium Bacillus subtilis under nutrient
perturbations, protein depletion, and antibiotic treatments, we find that cell geometry is …

Thinking big: the tunability of bacterial cell size

S Cesar, KC Huang - FEMS microbiology reviews, 2017 - academic.oup.com
The determination of cell size is a fundamental challenge for all living organisms. In a given
growth condition, cell size for a particular bacterial species typically falls within a narrow …

[PDF][PDF] Relative rates of surface and volume synthesis set bacterial cell size

LK Harris, JA Theriot - Cell, 2016 - cell.com
Many studies have focused on the mechanisms underlying length and width determination
in rod-shaped bacteria. Here, we focus instead on cell surface area to volume ratio (SA/V) …