Background/Aim: Several links between DNA replication, pluripotency and development
have been recently identified. The involvement of miRNA in the regulation of cell cycle …

Pluripotent stem cells are characterized by the capacity to self-renew and to differentiate into
all the cell types of the body. To identify novel regulators of pluripotency, we screened cDNA …

Molecular mechanisms governing maintenance, commitment, and differentiation of stem
cells are largely unexploited. Molecules involved in the regulation of multiple cellular …

The geminin protein is a critical regulator of DNA replication. It functions to control replication
fidelity by blocking the assembly of prereplication complexes in the S and G 2 phases of the …

DNA rereplication leads to genomic instability and has been implicated in the pathology of a
variety of human cancers. Eukaryotic DNA replication is tightly controlled to ensure it occurs …

Geminin is an essential cell-cycle protein that is only present from S phase to early mitosis in
metazoan somatic cells [1, 2]. Genetic ablation of geminin in the mouse results in …

Pluripotency requires the expression of the three core transcriptions factors Oct4, Sox2 and
Nanog, as well as further, complementary proteins. The geminin protein is part of this …

Geminin is a dual-function protein unique to multicellular animals with roles in modulating
gene expression and preventing DNA re-replication. Here, we show that geminin is …

Simple Summary The cell division cycle is tightly regulated to ensure faithful and complete
DNA replication. A critical cell cycle phase is G1 in which cells prepare DNA for replication in …

The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells
and driving tumorigenesis. We previously showed that PKC activity is involved in the …