During cancer genesis, the extracellular matrix (ECM) in the human brain undergoes
important transformations, starting to resemble embryonic brain cell milieu with a much …

Introduction Glioblastoma (GBM), the most frequent type of brain tumour in adults, is highly
aggressive and invasive. No curative treatment is currently available for GBM; patient …

Abstract The Central Nervous System (CNS) is a highly complex organ that works as the
control centre of the body, managing vital and non-vital functions. Neuro-diseases can lead …

Simple Summary The new trends in the research on glioblastomas (GBMs) are focusing on
understanding the crosstalk between proper neoplastic tissue and its microenvironment …

Glioblastoma is the most common and deadly human brain cancers. Unique barriers hinder
the drug delivering pathway due to the individual position of glioblastoma, including blood …

Extracellular matrix is a complex network of macromolecules that constitute a
microenvironment of normal tissues and malignancies such as the primary brain tumor …

Glioblastoma multiforme (GBM) has several distinctive characteristics linked to a poor early-
stage prognosis. The crucial obstacle in the treatment of GBM is the inability of chemo drugs …

Glioblastoma (GBM), or grade IV glioma, is an extremely aggressive tumor that infiltrates
through the brain leaving the patient with a median survival time from 12 to 15 months …

Glioblastoma (GBM) is the most common primary brain tumor and has a poor prognosis; as
such, there is an urgent need to develop innovative new therapies. Tumoricidal stem cells …

Neurodegenerative disorders (ie, Alzheimer's disease, Parkinson's disease, amyotrophic
lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are …