Microsatellite instability and programmed cell death-ligand 1 expression in stage II/III gastric cancer: post hoc analysis of the CLASSIC randomized controlled study
Objective: We investigated microsatellite instability (MSI) status and programed cell death
ligand 1 (PD-L1) expression as predictors of prognosis and responsiveness to …
ligand 1 (PD-L1) expression as predictors of prognosis and responsiveness to …
Prognostic and predictive value of microsatellite instability, inflammatory reaction and PD‐L1 in gastric cancer patients treated with either adjuvant 5‐FU/LV or …
M Di Bartolomeo, F Morano, A Raimondi… - The …, 2020 - academic.oup.com
Background Patients with high microsatellite instability (MSI) gastric cancer (GC) show
improved survival and no benefit or harm from adjuvant and/or perioperative chemotherapy …
improved survival and no benefit or harm from adjuvant and/or perioperative chemotherapy …
Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5‐FU based chemotherapy after R0 resection
JY An, H Kim, JH Cheong, WJ Hyung… - … journal of cancer, 2012 - Wiley Online Library
This study investigated whether MSI status can be used as a prognostic biomarker and
whether it is helpful for predicting which patients will benefit from 5‐FU based adjuvant …
whether it is helpful for predicting which patients will benefit from 5‐FU based adjuvant …
[HTML][HTML] Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches
M Ratti, A Lampis, JC Hahne, R Passalacqua… - Cellular and Molecular …, 2018 - Springer
Gastric cancer is one of the most aggressive malignancies, with limited treatment options in
both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic …
both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic …
[HTML][HTML] Programmed cell death-ligand 1 expression predicts survival in patients with gastric carcinoma with microsatellite instability
J Cho, J Lee, H Bang, ST Kim, SH Park, JY An… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Programmed death-ligand 1 (PD-L1) is expressed in a subgroup of gastric cancers
that may benefit from immunotherapy. Microsatellite instability-high (MSI-H) is a potential …
that may benefit from immunotherapy. Microsatellite instability-high (MSI-H) is a potential …
[HTML][HTML] Predictive value of MLH1 and PD-L1 expression for prognosis and response to preoperative chemotherapy in gastric cancer
T Hashimoto, Y Kurokawa, T Takahashi, Y Miyazaki… - Gastric Cancer, 2019 - Springer
Background Microsatellite instability (MSI) and programmed death-ligand 1 (PD-L1) are
candidate predictors for the response to immune checkpoint inhibitors, and may predict …
candidate predictors for the response to immune checkpoint inhibitors, and may predict …
The benefit of microsatellite instability is attenuated by chemotherapy in stage II and stage III gastric cancer: results from a large cohort with subgroup analyses
SY Kim, YY Choi, JY An, HB Shin, A Jo… - … Journal of Cancer, 2015 - Wiley Online Library
We previously reported that the prognosis of microsatellite instability high (MSI‐H) gastric
cancer is similar to that of MSI‐low/microsatellite stable (MSI‐L/MSS) gastric cancer. The …
cancer is similar to that of MSI‐low/microsatellite stable (MSI‐L/MSS) gastric cancer. The …
Chemosensitivity and survival in gastric cancer patients with microsatellite instability
Introduction Conflicting data exist regarding the relevance of high-frequency microsatellite
instability (MSI-H) for predicting the prognosis and benefits of 5-fluorouracil (5-FU)-based …
instability (MSI-H) for predicting the prognosis and benefits of 5-fluorouracil (5-FU)-based …
Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer
F Pietrantonio, R Miceli, A Raimondi… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE In the CLASSIC and MAGIC trials, microsatellite instability (MSI)–high status was
a favorable prognostic and potential negative predictive factor for neoadjuvant/adjuvant …
a favorable prognostic and potential negative predictive factor for neoadjuvant/adjuvant …
Prognostic significance of microsatellite‐instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy
GM Haag, E Czink, A Ahadova… - … journal of cancer, 2019 - Wiley Online Library
Perioperative systemic treatment is standard of care for Caucasian patients with locally
advanced, resectable gastric adenocarcinoma. The prognostic relevance of the …
advanced, resectable gastric adenocarcinoma. The prognostic relevance of the …
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