Insulin action in the hypothalamus results in the suppression of hepatic glucose production
(HGP). Obesity is often associated with a diminished response to insulin, leading to impaired …

Background: Obesity is associated with reduced physiological responses to leptin and
insulin, leading to the concept of obesity-associated hormonal resistance. Objectives: Here …

Protein-tyrosine phosphatase 1B (PTP1B) regulates food intake (FI) and energy expenditure
(EE) by inhibiting leptin signaling in the hypothalamus. In peripheral tissues, PTP1B …

Leptin has been shown to improve insulin sensitivity and glucose metabolism in obese
diabetic ob/ob mice, yet the mechanisms remain poorly defined. We found that 2 d of leptin …

Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed tyrosine phosphatase
implicated in the negative regulation of leptin and insulin receptor signaling. PTP1B−/− mice …

Leptin signaling in the central nervous system, and particularly the arcuate hypothalamic
nucleus, is important for regulating energy and glucose homeostasis. However, the roles of …

Recent evidence suggests that hormones such as insulin and leptin act in the hypothalamus
to regulate energy balance and glucose metabolism. Here we show that in leptin receptor …

Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate
nucleus (ARH) has been proposed as an important site of leptin action. To assess the …

The importance of hypothalamic leptin and insulin resistance in the development and
maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine …

Protein tyrosine phosphatase 1B (PTP1B) contributes to leptin resistance by inhibiting
intracellular leptin receptor signaling. Mice with whole body or neuron-specific deletion of …