TSLP: from allergy to cancer

J Corren, SF Ziegler - Nature immunology, 2019 - nature.com
The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis
and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 …

Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses

S Nakajima, H Kabata, K Kabashima… - Allergology …, 2020 - jstage.jst.go.jp
abstract TSLP is an epithelial cell-derived cytokine synthesized in response to various
stimuli, including protease allergens and microorganisms like viruses and bacteria …

TSLP: finally in the limelight

WJ Leonard - Nature immunology, 2002 - nature.com
TSLP: finally in the limelight | Nature Immunology Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the …

TSLP: a key regulator of asthma pathogenesis

EE West, M Kashyap, WJ Leonard - Drug Discovery Today: Disease …, 2012 - Elsevier
Asthma is a complex disorder of the airways that is characterized by T helper type 2 (Th2)
inflammation. The pleiotrophic cytokine TSLP has emerged as an important player involved …

Cellular and molecular mechanisms of TSLP function in human allergic disorders-TSLP programs the" Th2 code" in dendritic cells

T Ito, YJ Liu, K Arima - Allergology International, 2012 - jstage.jst.go.jp
Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for
initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface. In humans …

TSLP enhances the function of helper type 2 cells

M Kitajima, HC Lee, T Nakayama… - European journal of …, 2011 - Wiley Online Library
The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development
and progression of allergic inflammation in both humans and mice. TSLP has been shown to …

[HTML][HTML] The influence of TSLP on the allergic response

MR Comeau, SF Ziegler - Mucosal immunology, 2010 - Elsevier
Exposure to allergens first occurs at body surfaces in direct contact with the environment
such as the skin, airways, and gastrointestinal tract, and compelling evidence suggests that …

Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

V Soumelis, PA Reche, H Kanzler, W Yuan… - Nature …, 2002 - nature.com
Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2
(TH2)-type allergic inflammation is not known. We show here that human thymic stromal …

Modulation of signaling mediated by TSLP and IL-7 in inflammation, autoimmune diseases, and cancer

I Marković, SN Savvides - Frontiers in immunology, 2020 - frontiersin.org
Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines
within distinct branches of immunology. On one hand, TSLP is crucially important for …

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

K Verstraete, F Peelman, H Braun, J Lopez… - Nature …, 2017 - nature.com
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the
pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) …