Tremendous progress has been made in the genetic elucidation of obesity over the past two
decades, driven largely by technological, methodological and organizational innovations …

Obesity is a complex and multifactorial disease that occurs as a result of the interaction
between “obesogenic” environmental factors and genetic components. Although the genetic …

Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …

The genetic architecture of obesity is still a matter of debate. The previously accepted
hypothesis of a small number of common variants has been undermined by the low …

The last few years have seen major advances in common non-syndromic obesity research,
much of it the result of genetic studies. This Review outlines the competing hypotheses …

Genome-wide association promises to enhance greatly our understanding of the genetic
basis of common obesity, although candidate gene studies will remain a valuable approach …

Despite a relatively high heritability, the search for obesity-susceptibility genes has been
challenging. While over the past 15 years, candidate gene studies and genome-wide …

The prevalence of obesity, which is a heritable trait that arises from the interactions of
multiple genes and lifestyle factors, continues to increase worldwide, causing serious health …

Obesity and related complications are major health burdens. Almost 700 million adults are
currently obese globally and the prevalence is predicted to rise towards 2030. The sudden …

Candidate gene and genome-wide association studies have led to the discovery of nine loci
involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These …