Pharmacologic modulation of bile acid-FXR-FGF15/FGF19 pathway for the treatment of nonalcoholic steatohepatitis

JD Schumacher, GL Guo - Bile Acids and Their Receptors, 2019 - Springer
Nonalcoholic steatohepatitis (NASH) is within the spectrum of nonalcoholic fatty liver
disease (NAFLD) and can progress to fibrosis, cirrhosis, and even hepatocellular carcinoma …

[HTML][HTML] Role of FXR in bile acid and metabolic homeostasis in NASH: pathogenetic concepts and therapeutic opportunities

R Radun, M Trauner - Seminars in Liver Disease, 2021 - thieme-connect.com
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent cause of liver
disease, increasingly contributing to the burden of liver transplantation. In search for …

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

L Adorini, M Pruzanski, D Shapiro - Drug discovery today, 2012 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver condition
evolving in a proportion of patients into nonalcoholic steatohepatitis (NASH), an aggressive …

Non‐alcoholic fatty liver disease: the bile acid‐activated farnesoid x receptor as an emerging treatment target

M Fuchs - Journal of lipids, 2012 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver
disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to …

[HTML][HTML] Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets

S Maliha, GL Guo - Liver Research, 2021 - Elsevier
The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated
by bile acids or synthetic FXR agonists. FXR is expressed highly in the liver and intestine …

[HTML][HTML] Why bile acids are so important in non-alcoholic fatty liver disease (NAFLD) progression

A Gottlieb, A Canbay - Cells, 2019 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a complex disease, affecting not just the liver,
but also all other organs in the body. Despite an increasing amount of people worldwide …

Miniseries: Established pharmacological targets for NASHFXR agonists in NASH treatment

L Adorini, M Trauner - Journal of Hepatology, 2023 - Elsevier
The farnesoid X receptor (FXR), a bile acid (BA)-activated nuclear receptor highly expressed
in liver and intestine, regulates the expression of genes involved in cholesterol and bile acid …

[HTML][HTML] Fatty liver diseases, bile acids, and FXR

Y Zhu, H Liu, M Zhang, GL Guo - Acta Pharmaceutica Sinica B, 2016 - Elsevier
The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide has increased at an
alarming rate, which will likely result in enormous medical and economic burden. NAFLD …

[HTML][HTML] Transcriptome analysis of dual FXR and GPBAR1 agonism in rodent model of NASH reveals modulation of lipid droplets formation

A Carino, S Marchianò, M Biagioli, C Fiorucci… - Nutrients, 2019 - mdpi.com
Non-alcoholic steatohepatitis (NASH) is a progressive, chronic, liver disease whose
prevalence is growing worldwide. Despite several agents being under development for …

[HTML][HTML] Targeting bile acids and lipotoxicity for NASH treatment

JYL Chiang - Hepatology communications, 2017 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting
approximately 20%-30% of the population in Western countries. Nonalcoholic …