Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: a multidatabase cohort study
Objective To investigate the rate of serious bacterial, viral or opportunistic infection in
patients with rheumatoid arthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis …
patients with rheumatoid arthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis …
Risk of malignancy associated with use of tocilizumab versus other biologics in patients with rheumatoid arthritis: a multi-database cohort study
Objectives To examine the rate of incident malignancies excluding non-melanoma skin
cancer (NMSC) in patients with rheumatoid arthritis (RA) newly treated with tocilizumab …
cancer (NMSC) in patients with rheumatoid arthritis (RA) newly treated with tocilizumab …
Risk of infections in rheumatoid arthritis patients treated with tocilizumab
VR Lang, M Englbrecht, J Rech, H Nüsslein… - …, 2012 - academic.oup.com
Objectives. To investigate the occurrence and risk factors for infections in RA patients treated
with tocilizumab. Methods. A cohort of all RA patients (n= 112) starting tocilizumab therapy …
with tocilizumab. Methods. A cohort of all RA patients (n= 112) starting tocilizumab therapy …
[HTML][HTML] Low immunogenicity of tocilizumab in patients with rheumatoid arthritis
GR Burmester, E Choy, A Kivitz, A Ogata… - Annals of the …, 2017 - ard.bmj.com
Objective Subcutaneous (SC) and intravenous formulations of tocilizumab (TCZ) are
available for the treatment of patients with rheumatoid arthritis (RA), based on the efficacy …
available for the treatment of patients with rheumatoid arthritis (RA), based on the efficacy …
Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: a large, open-label study close to clinical practice
VP Bykerk, AJK Östör, J Alvaro-Gracia… - Annals of the …, 2012 - ard.bmj.com
Objective To evaluate the safety and efficacy of tocilizumab in clinical practice in patients
with rheumatoid arthritis (RA) with inadequate responses (IR) to disease-modifying …
with rheumatoid arthritis (RA) with inadequate responses (IR) to disease-modifying …
[PDF][PDF] Cardiovascular safety of tocilizumab versus tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a multi‐database cohort study
SC Kim, DH Solomon, JR Rogers, S Gale… - Arthritis & …, 2017 - Wiley Online Library
Objective While tocilizumab (TCZ) is known to increase low‐density lipoprotein (LDL)
cholesterol levels, it is unclear whether TCZ increases cardiovascular risk in patients with …
cholesterol levels, it is unclear whether TCZ increases cardiovascular risk in patients with …
Head-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the …
R Sakai, SK Cho, T Nanki, K Watanabe… - Arthritis research & …, 2015 - Springer
Introduction The objective of this study was to directly compare the safety of tocilizumab
(TCZ) and TNF inhibitors (TNFIs) in rheumatoid arthritis (RA) patients in clinical practice …
(TCZ) and TNF inhibitors (TNFIs) in rheumatoid arthritis (RA) patients in clinical practice …
Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of …
L Campbell, C Chen, SS Bhagat, RA Parker… - …, 2011 - academic.oup.com
Objective. To assess the risk of adverse events (AEs) in patients with RA treated with
tocilizumab, an IL-6 receptor antibody, in published randomized controlled trials (RCTs) …
tocilizumab, an IL-6 receptor antibody, in published randomized controlled trials (RCTs) …
Integrated safety in tocilizumab clinical trials
MH Schiff, JM Kremer, A Jahreis, E Vernon… - Arthritis research & …, 2011 - Springer
Introduction The efficacy and safety of tocilizumab in patients with rheumatoid arthritis have
been evaluated in a comprehensive phase 3 program. Patients from these randomized trials …
been evaluated in a comprehensive phase 3 program. Patients from these randomized trials …
Effectiveness of tocilizumab with and without synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a European collaborative study
Objectives To examine the effectiveness of tocilizumab (TCZ) with and without synthetic
disease-modifying antirheumatic drugs (sDMARDs) in a large observational study. Methods …
disease-modifying antirheumatic drugs (sDMARDs) in a large observational study. Methods …
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