Background: Nicotine, because of its volatility, has a complex dosimetry following inhalation
as a vapor/aerosol mix. To better control the dosimetry, nicotine could be formulated with a …

Absorption of inhaled compounds can occur from multiple sites based on upper and lower
respiratory tract deposition, and clearance mechanisms leading to differential local and …

Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for
characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a …

One of the challenges for toxicological assessment of inhaled aerosols is to accurately
predict their deposited and absorbed dose. Transport, evolution, and deposition of liquid …

A formulation of tobacco extract containing 4% nicotine (TE) and similar nicotine formulation
containing vehicle and 4% nicotine (NF) were evaluated using animal inhalation assays …

In the past few years, technological advancements enabled the development of novel
electronic nicotine delivery systems (ENDS). Several empirical measures such as “nicotine …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

Purpose The ability of two semi-mechanistic simulation approaches to predict the systemic
pharmacokinetics (PK) of inhaled corticosteroids (ICSs) delivered via dry powder inhalers …

Recently, inhaled immunosuppressive agents have attracted increasing attention for
maintenance therapy following lung transplantation. The rationale for this delivery approach …

Introduction: A considerable minority of adults remain addicted to smoking cigarettes despite
substantial education and public health efforts. Nicotine replacement therapies have only …