Cranial growth and development is a complex process which affects the closely related traits
of head circumference (HC) and intracranial volume (ICV). The underlying genetic …

Intracranial volume reflects the maximally attained brain size during development, and
remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes …

During aging, intracranial volume remains unchanged and represents maximally attained
brain size, while various interacting biological phenomena lead to brain volume loss …

Atypical head circumference (HC) growth has been associated with neurodevelopmental
disorders. However, whether it is associated with specific aspects of development in early …

Mutations disabling the TP53 tumour suppressor gene represent the most frequent events in
human cancer and typically occur through a two-hit mechanism involving a missense …

To identify genetic variants associated with head circumference in infancy, we performed a
meta-analysis of seven genome-wide association studies (GWAS)(N= 10,768 individuals of …

Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein
p53 (TP53) are missense mutations,. Mutant p53 protein is often abundantly expressed in …

TP53 is the most frequently mutated gene in cancer and its study helped to define
fundamental principles underlying tumorigenesis. However, despite over three decades of …

Genetic influences on cortical thickness (CT) and surface area (SA) are known to vary
across the life span. Little is known about the extent to which genetic factors influence CT …

Besides being a critical tumor suppressor, the TP53 gene also plays a role in metabolism
and recent studies in humans have implicated the codon 72 polymorphism of TP53 in this …