Neurodegenerative diseases of the central nervous system progressively rob patients of
their memory, motor function, and ability to perform daily tasks. Advances in genetics and …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Alzheimer's disease (AD) is the sixth leading cause of death in the United States and the
most common cause of dementia in the elderly. Genetic factors, such as rare variants in the …

It is clear that innate immune system status is altered in numerous neurodegenerative
diseases. Human genetic studies have demonstrated that triggering receptor expressed in …

Neuroinflammation is an important contributor to Alzheimer9s disease (AD) pathogenesis,
as underscored by the recent identification of immune-related genetic risk factors for AD …

The central role of the resident innate immune cells of the brain (microglia) in
neurodegeneration has become clear over the past few years largely through genome-wide …

Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of
pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and …

Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor exclusively
expressed by microglia in the brain, modulates microglial immune homeostasis. Human …

Alzheimer's Disease (AD) is age-related neurodegenerative disorder recognized by a
steadily gradual cognitive decline that has devastating personal and socioeconomic …

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …